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Creators/Authors contains: "Umen, James_G"

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  1. Significance Studies of eukaryotic cell division have focused on the actomyosin ring, whose filaments of F-actin and myosin-II are hypothesized to generate the contractile force for ingression of the cleavage furrow. However, myosin-II has a very limited taxonomic distribution, whereas division by furrowing is much more widespread. We used the green algaChlamydomonas reinhardtiito investigate how a furrow can form without myosin-II and the potential roles of F-actin in this process. Although F-actin was associated with ingressing furrows, its complete removal only modestly delayed furrowing, suggesting that an actin-independent mechanism (possibly involving microtubules) drives furrow ingression. Such a mechanism presumably emerged early in eukaryotic evolution and may still underlie cell division in a diverse range of modern species. 
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